Serum lipid profiling in decompensated patients with Hepatitis B virus -related cirrhosis
DOI: 10.54647/cm321189 71 Downloads 244788 Views
Author(s)
Abstract
Background: The association of lipid profile with decompensation in patients with liver cirrhosis has not been clarified. The present study aimed to investigate the impact of Hepatitis B virus (HBV) infection on the lipid profile in decompensated patients with hepatitis B cirrhosis.
Methods: A total of 178 HBV-related decompensated cirrhosis (HBV-DeCi) patients were included in this retrospective analysis. The included patients were subdivided into 4 groups: 24 patients with HBsAg, HBeAg and HBcAb positive were set as group Ia; 14 patients with HBsAg, HBeAg ,HBeAb and HBcAb positive were set as group Ib;112 patients with HBsAg, HBeAb and HBcAb positive were set as group II; 28 patients with HBsAb, HBeAb and HBcAb positive were set as group III. Lipid profile included total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein- cholesterol (LDL-c), triglycerides (TG), and lipoprotein(a) (Lpa) were analyzed respectively. The difference between mentioned groups and the HBV infection were characterized respectively.
Results: Our data showed that the values of TG in group Ia was 1.2181 ± 0.1898 (mmol/L), in Ib was 1.306 ± 0.1702 (mmol/L), in Ia+Ib was 1.29 ± 0.1338 (mmol/L), and in group III was 0.8950±0.07200 (mmol/L). There were significant differences between group Ia and III (P=0.0498), Ib and III (P=0.0125) and also between group Ia+Ib and III (P=0.0217).
Conclusions: Serum TG levels are closely related to the HBV infection in HBV-DeCi patients. It may be used as a new indicator of advanced liver disease and cirrhosis recompensation.
Keywords
hepatitis B virus, decompensated cirrhosis, Lipid profile
Cite this paper
Changzhi Xu, Yanhua Yi, Zhizhi Xie, Donglin Zhu, Zhu Wang, Yun Xi,
Serum lipid profiling in decompensated patients with Hepatitis B virus -related cirrhosis
, SCIREA Journal of Clinical Medicine.
Volume 8, Issue 5, October 2023 | PP. 361-369.
10.54647/cm321189
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