Efficiency of platinum-based chemotherapy re-induction for adrenocortical cancer treatment
DOI: 10.54647/cm32932 83 Downloads 3746 Views
Author(s)
Abstract
The combination of platinum-based chemotherapy with mitotane (m) is the standard first-line therapy for metastatic adrenocortical cancer (ACC) with long-term disease control in approximately 25% of patients. Considering the lack of effective regimens for second and subsequent lines of therapy, it seems relevant to evaluate the effectiveness of platinum-based chemotherapy re-induction for patients with long platinum-free interval. Aim:Evaluation of the platinum-based chemotherapy re-induction efficiency with or without mitotane for patients with metastatic ACC.Materials and methods:This retrospective clinical study included patients with disease progression ≥ 6 months after completion of platinum-based chemotherapy for metastatic ACC. Results:17 patients were included, of which 16 received EDP+/-m regimen and 1 - EP. The median platinum-free interval was 8.3 months (7.2-39.7). Concurrent mitotane therapy was administered in 14 patients (82.35%), all of them achieved therapeutic concentration. Objective response and disease control ≥6 months rate were observed in 23.52% (N=4) and 52.94% (N=9), respectively. The median progression-free survival was 6.17 months, and the median overall survival 15.63 months.Conclusion:This study demonstrated the efficacy of platinum-based chemotherapy re-induction in metastatic ACC. The selected group of patients in our study with relatively platinum-sensitive disease does not allow to perform cross trial comparisons. Based on the results described above, we recommend considering re-induction of platinum-based chemotherapy with mitotane for patients with a platinum-free interval of ≥6 months as an option of second or further lines of treatment.
Keywords
adrenocortical cancer, re-induction, platinum-based chemotherapy, EDP, mitotane
Cite this paper
Zhulikov Ya., Kovalenko E., Bokhian V., Evdokimova E., Khoroshilov M., Gabrava M., Kolobanova E., Artamonova E.,
Efficiency of platinum-based chemotherapy re-induction for adrenocortical cancer treatment
, SCIREA Journal of Clinical Medicine.
Volume 7, Issue 5, October 2022 | PP. 302-311.
10.54647/cm32932
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