CORRELATION BETWEEN GLOMERULAR FILTRATION RATE WITH CALCIUM-PHOSPHATE PRODUCT LEVELS IN CHRONIC KIDNEY DISEASE
DOI: 10.54647/cm32848 86 Downloads 3760 Views
Author(s)
Abstract
Background: In chronic kidney disease (CKD) patients, calcium and phosphate homeostasis disorders occur. Decreased renal function will result in a decrease in phosphate excretion. In stage 3b CKD, the kidney is no longer able to compensate for phosphate burden adequately, and as a result hyperphosphatemia arises. The decline in renal function also causes calcitriol level to decline, which will be followed by undermined calcium absorption in the intestine. The application of calcium-phosphate binders and calcitrion in CKD will normalize phosphate and calcium levels in the blood. However, it can bring about hypercalcemia episodes. This research attempted to figure out the relationship between glomerular filtration rate (GFR) and calcium-phosphate (CaxP) product in CKD.
Methods: This is an observational study with a cross-sectional approach that involved 80 CKD subjects, distributed into stage 3 (n = 20), stage 4 (n = 20), non-dialysis stage 5 (n = 20), and dialysis stage 5 (n = 20) CKD patients at Wahidin Sudirohusodo Hospital and Unhas Hospital of Makassar from April to August of 2021. Phosphate levels were measured using ELISA kit (Immutopics). The results of the statistical tests conducted would be considered significant if p < 0.05.
Results: The CaxP product averages across stages were as follows: stage 3: 32.82 ± 10.77 mg2/dL2; stage 4: 32.95 ± 8.11 mg2/dL2; non-dialysis stage 5: 47.93 ± 21.28 mg2/dL2; and dialysis stage 5: 45.58 ± 24.74 mg2/dL2. The figures above showed that stage 3 was not significantly different from stage 4 (p = 0.986), but it was significantly different from non-dialysis stage 5 (p = 0.009). A significant difference was also found between stage 4 and non-dialysis stage 5 (p = 0.009). The proportion of subjects with high CaxP product (CaxP > 55 mg2/dL2) in CKD stage 3 was 5% (n = 1), in CKD stage 4 5% (n = 1), in non-dialysis stage 5 25% (n = 5), and in dialysis stage 5 35% (n = 7).
Conclusion: The lower the GFR the greater the CaxP product. The proportion of subjects with high CaxP product increased with the decrease in GFR.
Keywords
Phosphate; Calcium-Phosphate Product; Glomerular Filtration Rate; Chronic Kidney Disease
Cite this paper
Rizki Primasari, Hasyim Kasim, Arifin Seweng, Andi Muhammad Luthfi Parewangi, Endy Adnan, Syakib Bakri, Haerani Rasyid,
CORRELATION BETWEEN GLOMERULAR FILTRATION RATE WITH CALCIUM-PHOSPHATE PRODUCT LEVELS IN CHRONIC KIDNEY DISEASE
, SCIREA Journal of Clinical Medicine.
Volume 7, Issue 4, August 2022 | PP. 224-231.
10.54647/cm32848
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