The concentration of CEA and Cyfra 21-1 in patients with non-small cell lung cancer treated with tyrosine kinase inhibitors

Tong Quoc Dong; Ho Thi Long; Nguyen Thi Thu Hien; Doan Vu Nam; Pham Thai Binh; Pham Van Tran

doi:10.54647/pm31142

ISSN: 2995-7060

Volume 5, Number 6 (2021)

Year Launched: 2016

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The concentration of CEA and Cyfra 21-1 in patients with non-small cell lung cancer treated with tyrosine kinase inhibitors

Volume 5, Issue 6, December 2021 | PP. 62-74 | PDF (429 K) | Pub. Date: November 16, 2021
DOI: 10.54647/pm31142 80 Downloads 62584 Views

Author(s)

Tong Quoc Dong, Faculty of postgraduate education, Vietnam Military Medical University, Ha Dong, Ha Noi, Viet Nam

Ho Thi Long, Department of Biochemistry, 103 Military Medical Hospital, Ha Dong, Ha Noi, Viet Nam

Nguyen Thi Thu Hien, Department of Biochemistry, K Tan Trieu Hospital, Thanh Tri, Ha Noi, Viet Nam

Doan Vu Nam, Department of internal medicine, Military Hospital 175, Go Vap, Ho Chi Minh, Viet Nam

Pham Thai Binh, Department of internal medicine, 103 Military Medical Hospital, Ha Dong, Ha Noi, Viet Nam

Pham Van Tran, Department of Biochemistry, 103 Military Medical Hospital, Ha Dong, Ha Noi, Viet Nam

Abstract
Objective: The purpose of this study was to determine CEA and Cyfra 21-1 concentrations in plasma of patients with non- small cell lung cancer before and after three months, six months of treatment with tyrosine kinase inhibitors.
Methods: 400 patients with non-small cell lung cancer were first treated with tyrosine kinase inhibitors (gefitinib or erlotinib). Before and after three months, six months of treatment, the patients were evaluated the clinical symptoms, chest computed tomography and quantified CEA, Cyfra 21-1 concentrations in plasma.
Results: In patients with non-small cell lung cancer, CEA and Cyfra 21-1 data followed an abnormal distribution with the median of 18.94 (range: 1.79 – 1553.0) and a median of 6.52 (range: 1.51 – 590.0), respectively. There was a strong positive correlation between CEA and Cyfra 21-1 concentrations (r = 0.84). CEA and Cyfra 21-1 concentrations decreased after treatment with tyrosine kinase inhibitors but the difference was not statistically significant (p > 0.05).
Conclusions: CEA and Cyfra 21-1 are significant markers for diagnosis and follow-up in patients with non- small cell lung cancer treated with tyrosine kinase inhibitors.

Keywords
CEA, Cyfra 21-1, erlotinib, gefitinib, non- small cell lung cancer

Cite this paper
Tong Quoc Dong, Ho Thi Long, Nguyen Thi Thu Hien, Doan Vu Nam, Pham Thai Binh, Pham Van Tran, The concentration of CEA and Cyfra 21-1 in patients with non-small cell lung cancer treated with tyrosine kinase inhibitors , SCIREA Journal of Medicine. Volume 5, Issue 6, December 2021 | PP. 62-74. 10.54647/pm31142

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