Zaiqiang-HUANG, Wenshan College，Wenshan Biological Resources Development and Research Center Wenshan，China; Yunnan Key Laboratory of Panax Notoginseng Kunming，China.

Lin-ZHU, Wenshan College，Wenshan Biological Resources Development and Research Center Wenshan，China.

Ni-MA, Wenshan College，Wenshan Biological Resources Development and Research Center Wenshan，China.

Minju-GAO, Wenshan College，Wenshan Biological Resources Development and Research Center Wenshan，China; Yunnan Key Laboratory of Panax Notoginseng Kunming，China.

Abstract
Panax notoginseng (notoginseng) is one of the typical traditional Chinese medicines(TCM) with great medicinal and health care value. Notoginseng has the effects of hemostasis, dispersing blood stasis and reducing swelling, while cooked notoginseng has a weak effect of hemostasis and removing blood stasis, but it can nourish and nourish. In recent years, the processing of notoginseng and its effect on the medicinal effect of notoginseng have attracted much attention from scholars.In view of the lack of normative and systematic research on the processing of notoginseng, and the lack of research on the processing of raw notoginseng to promote blood circulation and remove blood stasis and cooked notoginseng to replenish qi and blood, the author put forward the research concept on the prescription of Chinese medicine chemical composition according to the prescription relationship among Monarch, Minister, Assistant and Guide of TCM, and opened up a new way for the processing and pharmacological research of notoginseng.

Keywords
Notoginseng; Processing; Chemical prescription of traditional Chinese medicine; Stop bleeding and remove blood stasis; Blood

Cite this paper
Zaiqiang-HUANG, Lin-ZHU, Ni-MA, Minju-GAO, Research Status and Discussion on the Processing and Efficacy about One of Large Variety of TCM on Panax Notoginseng , SCIREA Journal of Medicine. Volume 4, Issue 5, October 2020 | PP. 77-93.

References

[ 1 ]	K. Wugyun, C. Baoer, Z. Botao. Key techniques of Chinese medicinal materials breeding. Nanjing: jiangsu science and technology press, 2001.
[ 2 ]	X. Dongying. Research on the name of panqi and its written record . Guangxi university of traditional Chinese medicine, 2000,17 (3) : 911.
[ 3 ]	Y. Dngjiang, S. tong. Dictionary of TCM preparation. Shanghai: Shanghai science and technology press, 2004:206.
[ 4 ]	C. Bin, H. lin, X. bin. Research progress and ideas on the processing of panax notoginseng. Chinese herbal medicine, 2013,4 (4) : 482-487.
[ 5 ]	G. li, G. jing, L. Jiaheng. Study on free radical scavenging activity of panax notoginseng and its processed products in vitro. Journal of Chinese veterinary medicine, 2016 (6) : 17-21.
[ 6 ]	M. Ni, G. Mingju, Z. Jiang, et al. Comparison of saponins in fresh panax notoginseng and dry panax notoginseng. Chinese herbal medicine, 2004,35 (1).
[ 7 ]	Z. Jiaming, G. Mingju, M. Ni, et al. Preliminary study on blanching technology applied to fresh notoginseng tablets. Ginseng research, 2011,23 (1) : 16-18.
[ 8 ]	Z. Guoyan, Z. Jianjun, S. Yingying, et al. Vacuum freeze drying process of panax notoginseng. Chinese patent medicine, 2013,35 (11) : 2525-2528.
[ 9 ]	L. Meifeng, L. Yushi, W. Zhenyue, et al. Application of vacuum freezing technology in panax notoginseng drying . Anhui agricultural science, 2019, 47 (03) : 181-183+196.
[ 10 ]	Z. Xufeng, L. ke, L. Yongjun, et al. Analysis of characteristic chemical components before and after processing of polygonum multiflorum. Zhongnan pharmacy, 2016 (7) : 704-708.
[ 11 ]	H. Qian, L. Li, C. Shengli, et al. Study on preparation technology and quality control index of black bean juice. Chinese journal of mountain agricultural biology, 2016,35 (5) : 83-88.
[ 12 ]	W. yanqing, S. liang,L. Lili, et al. Acute toxicity of water extracts from different processed products of polygonum multiflorum thunb on mice. Chinese pharmacovigilance, 2017,14 (10) : 599-602.
[ 13 ]	D. Min. Comparative study on acute toxicity of ethanol extracts from different processed products of polygonum multiflorum thunb to mice .Chinese pharmacovigilance, 2017, 14 (10) : 31-34+38.
[ 14 ]	L. Ye, Z.Changfeng, L. hua. Analysis on the effect of processing technology on constituents of polygonum multiflorum. World latest medical information digest, 2018 (42) : 116.
[ 15 ]	T. Jiping, Z. Guangzheng, Z. Yunyun, et al. Determination of saponins in different processed products of panax notoginseng. Chinese herbal medicine, 2006,37 (8).
[ 16 ]	K. Jinhu, S. Yuqin, C. Zhongjian, et al. Effect of processed panax notoginseng powder by steaming method on saponin content. Shi zhen guoyi guoyao, 2003, 14 (8) : 475-476.
[ 17 ]	W. Shuang, G. Congliang, C. Xiuming, et al. HPLC method for simultaneous determination of 10 saponins in raw panax notoginseng and steamed panax notoginseng. Chinese herbal medicine, 2015,38 (8).
[ 18 ]	W. Ye, L. Weiqiao, L. Shujun, et al. Research progress on microwave drying technology and equipment for agricultural products. Packaging and food machinery, 2016, 34 (3) : 56-61.
[ 19 ]	G. Mingju, F. Guangquan, Z. Hongchao, et al. Effect of microwave drying on active constituents of panax notoginseng saponins. Chinese medicinal materials, 2010,33 (2) : 198-200.
[ 20 ]	H. Qiong, C. Chaoyin, F. Qimeng, et al. Research and specification on processing of notoginseng. Contemporary Chinese medicine, 2015,22 (5).
[ 21 ]	D. Min. Fermentation and processing of traditional Chinese medicine.2013.
[ 22 ]	S. Jing, M. Lin, L. Siqi, et al. Research progress of traditional Chinese medicine fermentation technology. Drug evaluation studies, 2011,34 (1) : 49-52.
[ 23 ]	Z. peng. Preliminary study on microbial fermentation of panax notoginseng.Yunnan university, 2006.
[ 24 ]	C. Shu, F. Lili, D. Zhilin, et al. Study on the fermentation process of panax notoginseng to produce total saponins. Journal of jilin agricultural university, 2013, 35 (2) : 215-220.
[ 25 ]	Y. Jingjuan. Fermentation-assisted extraction and activity evaluation of total saponins from panax notoginseng. Zhejiang university, 2013.
[ 26 ]	Q. Mo, Q. Zhidong, W. Weinan. Study on solid fermentation process of notoginseng residue by ganoderma lucidum. Journal of changchun university of Chinese medicine, 2016, 32 (2) : 263-265.
[ 27 ]	L. Guimei, J. Chengguo, J. Tianzhu. Orthogonal experiment to optimize processing technology of Fried notoginseng. Chinese journal of traditional Chinese medicine, 2016 (10) : 2403-2406.
[ 28 ]	W. Xiaoqing, X. Bohou, L. Zhaohuan, et al. Content comparison of saponins in different processed products of notoginseng. Chinese journal of traditional Chinese medicine, 2011 (4) : 841-843.
[ 29 ]	W. Shuang. Research progress on material basis and pharmacological effects of notoginseng "sheng da shu bu". Anhui agricultural science. 2015, 477 (08) : 50-53.
[ 30 ]	Z. Kaihua. Research progress on material basis and pharmacological effects of sanqi "sheng da shu bu". Clinical research of traditional Chinese medicine, 2018 (1) : 19-20.
[ 31 ]	W. Shuang, G. Congliang, C. Xiuming, et al. Effect of processing pretreatment on the content of panax notoginseng saponins in panax notoginseng. Chinese journal of hospital pharmacy, 2015, 35 (24) : 2208-2212.
[ 32 ]	C. K. Xiu, Y. Lei , Q. Wang, et al. Effects of ginseng, notoginseng, and Chuanxiong Rhizoma extracts on cytoskeleton protein of replicative senescence vascular smooth muscle cells. China Journal of Chinese Materia Medica, 2016, 41 (3) : 484.
[ 33 ]	P. Xia, H. Guo, R. Mei, et al. An integral of saponins in Panax notoginseng during its growing seasons. Industrial & Products, 2017, 104:287-292.
[ 34 ]	W. Zhen, Y. Jingya, S. Shujie, et al. Effects of panax notoginseng on coagulation function and hemostatic mechanism. Chinese journal of new drugs, 2014 (3) : 356-359.
[ 35 ]	D. Wan, Q. Jie, B. Liu, et al. Saponin extract from notoginseng promoted sangiogenesis through ampk-and eNOS-dependent pathways in HUVECs. Molecular Medicine Reports, 2017, 16 (4) : 5211-5218.
[ 36 ]	B. R.Yang, S. J. Hong, M. Y.Lee, et al. Pro - angiogenic activity of notoginsenoside R1 in human umbilical vein endothelial cellsin vitroand in a chemical - induced blood vessel loss model of zebrafishin vivo. Chinese Journal of Integrative Medicine, 2016, 22 (6) : 420-429.
[ 37 ]	Z. Xinhui, L. Lili. L. Chunmei, et al. Comparative study on the pharmacological effects of panax notoginseng and steamed panax notoginseng. Global Chinese medicine, 2014 (6).
[ 38 ]	W. Zhe, L. Wei, Q. Yun. Observation on the clinical effect of sanqi powder on cancerous anemia.World TCM, 2015 (5).
[ 39 ]	D. Hongwei, X. Nanyun, C. Yi, et al. Clinical effect of sanqi powder on promoting the healing of femoral fracture and postoperative anemia. World TCM, 2015 (5).
[ 40 ]	X. Genzhen. Efficacy of sanqi in treating hemorrhagic anemia and preventing deep venous thrombosis after internal fixation with intramedullary nail of proximal femu. Journal of clinical rational drug use, 2015 (30) : 119-120.
[ 41 ]	W. Hong, L. Hua. Effect of sanqi powder on postoperative recovery of gynecology. World TCM, 2015 (5) : 644-646.