Jie Liu, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China; School of Medicine, Shenzhen University, Shenzhen 518060, China.

Huailing Wang, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China; College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.

Xiaowei Zeng, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

Xizhuo Sun, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China.

Zhendan He, College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.

Liteng Yang, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518020, China.

Shuqi Qiu, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, 518060, China.

Lin Mei, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

Abstract
Functions of Royal jelly polysaccharide have been widely explored, yet, the anti-tumor potency of Royal jelly peptides (RJPs) has never been explored. However, the anti-tumor property of RJPs was rarely explored. The present study evaluated the in vitro effects of RJPs on human gastric cancer cell lines. We found that RJP-1 (SHGEWL) significantly inhibited the proliferation of the MKN-45 cells in a does- and time-dependent manner. Further study revealed that RJP-1 regulated the p53/MDM2 state and blocked the cell cycle in the G0/G1 phase, which accompanied with inhibiting the CDK2, 4 and cyclin D, E expressions. In addition, RJP-1 significantly increased the Bax/Bcl-2 ratio and activated the Caspases, thereby inducing the MKN-45 cell apoptosis. The current findings reveal that the boiactive peptides in the Royal jelly maybe shining anti-cancer agents.

Keywords
Royal jelly; Gstric cancer; Cell cycle arrest, Apoptosis

Cite this paper
Jie Liu, Huailing Wang, Xiaowei Zeng, Xizhuo Sun, Zhendan He, Liteng Yang, Shuqi Qiu, Lin Mei, Peptides derived from Royal Jelly induce gastric cancer cells apoptosis by cell cycle arresting , SCIREA Journal of Medicine. Volume 4, Issue 1, February 2020 | PP. 10-30.

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