Conglomerate and Analgesic Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.
DOI: 10.54647/materials430259 29 Downloads 159164 Views
Author(s)
Abstract
Introduction: Quinazolinone by–product disclosed various curative characteristics such as analgesic, anti-inflammatory and anticancer activities, as well as antimicrobial activity. These heterocycles are beneficial intermediates in organic synthesis. Methods/Experimental:The compound, 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one(1) was integrated by dissolving 5-bromo anthranillic acid in 100 ml of pyridine. To this reaction mixture o-amino benzoyl chloride stirring at room temperature for 30 minutes this was refluxed with 75 mL of hydrazine hydrate for 3 hrs at 120-1300C. the reaction mixture was allowed to cool to room temperature to give 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one (2). These Compounds were evaluated for their analgesic activity using Acetic acid induced model. Study Design: This study was experimentally design and the analgesic activity was evaluated using Acetic acid induced model. Result: The compounds synthesized were evaluated pharmacologically for their in-vivo analgesic activities by acetic acid induced writhing in mice. The two scrutinized compounds exhibited significant analgesic activity in the range of 61.33 - 83.18% in comparison to control. Conclusions: From our findings, compound 2 synthesized have higher analgesic activities as compared to indomethacin a standard analgesic drug.
Keywords
Analgesic activity; Coglomerate; Quinazolinone derivatives; 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one; 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.
Cite this paper
Osarumwense Peter Osarodion,
Conglomerate and Analgesic Activity of 6-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 6-bromo,2-(o-aminophenyl)-3,1-benzoxazin-4(3H)-one.
, SCIREA Journal of Materials.
Volume 9, Issue 1, February 2024 | PP. 1-12.
10.54647/materials430259
References
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